Now showing items 1-3 of 3

    • [Genetic predisposition to multiple sclerosis as a polygenic autoimmune disease] 

      Favorova, Olʹga Olegovna; Favorov, Alexander V.; Boiko, Alexey N.; Sudomoina, Marina A.; Andreewski, Timofey V.; Alekseenkov, Alexey D.; Kulakova, O. G.; Gusev, E. I.; Parmigiani, Giovanni; Ochs, Michael F. (Izdatelstvo Meditsina, 2009)
      Unrelated patients with definite multiple sclerosis (MS) and healthy controls of Russian descent were genotyped at 16 polymorphic loci of the DRB1, TNF, LTa, TGFb1, CCR5 and CTLA4 genes and TNFa and TNFb microsatellites. ...
    • A Markov Chain Monte Carlo Technique for Identification of Combinations of Allelic Variants Underlying Complex Diseases in Humans 

      Ochs, Michael F.; Favorov, Alexander V.; Andreewski, Timofey V.; Sudomoina, Marina A.; Favorova, Olʹga Olegovna; Parmigiani, Giovanni (Genetics Society of America, 2005)
      In recent years, the number of studies focusing on the genetic basis of common disorders with a complex mode of inheritance, in which multiple genes of small effect are involved, has been steadily increasing. An improved ...
    • Three allele combinations associated with Multiple Sclerosis 

      Ochs, Michael F.; Favorova, Olʹga Olegovna; Favorov, Alexander V.; Boiko, Alexey N.; Andreewski, Timofey V.; Sudomoina, Marina A.; Alekseenkov, Alexey D.; Kulakova, O. G.; Gusev, E. I.; Parmigiani, Giovanni (BioMed Central, 2006)
      Background Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Dissection of its genetic background is a complex problem, because of the combinatorial possibilities of gene-gene interactions. As ...