Browsing by Author "Papamichail, Dimitris"
Now showing items 1-9 of 9
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Computational tools and algorithms for designing customized synthetic genes
(Frontiers Media, 2014)Advances in DNA synthesis have enabled the construction of artificial genes, gene circuits, and genomes of bacterial scale. Freedom in de novo design of synthetic constructs provides significant power in studying the impact ... -
Detecting Calling Male Frogs above the Background Chorus Noise
(2015)In this project, we created a computer simulation to emulate the conditions of natural choruses and previous playback experiments performed in the field. We also created a training program to employ machine learning ... -
Maximum Parsimony Advances for Native Phylogenetic Stemmatics
(2015)Our ultimate aim is to design an algorithm that generates the most parsimonious tree where extant texts may be ancestors of other texts. The algorithm accepts a set of extant manuscripts or a multiple alignment of such ... -
Maximum Parsimony Advances for Native Phylogenetic Stemmatics
(2015)In the field of textual criticism, scholars use stemmatics in order to recreate an extinct original text from a collection of extant copied texts. Stemmatic trees are used to represent the relationship between extant and ... -
Most compact parsimonious trees
(2016)Phylogeny is the evolutionary history of a set of species, represented in the form of a tree. Construction of phylogenetic trees has traditionally focused on binary trees where all species appear on leaves. However, certain ... -
Optimal synthetic protein variant libraries using combinatorial degenerate oligos
(2017)High throughput screening methods for proteins with improved properties (thermostability, binding affinity, catalytic activity) require evaluating large, diverse combinatorial libraries. This project focuses on algorithms ... -
Targeted cost-effective protein variant library design
(2022)In the field of synthetic biology, proteins are used for a wide range of applications, from medicine to biofuels to synthetic material. To enable such applications, it is often necessary to modify existing proteins and ...
