We have examined doxorubicin’s (DOX) physical state in solution and inside EPC/cholesterol liposomes that were loaded via a transmembrane pH gradient. Using cryogenic electron microscopy (cryo-EM) we noted that DOX loaded ...

16-Fluoropalmitic acid was synthesized from 16-hydroxypalmitic acid using diethylaminosulfur trifluoride. This monofluorinated fatty acid then was used to make 1-palmitoyl-2-[16-fluoropalmitoyl]-phosphatidylcholine (F-DPPC) ...

Dipolar decoupling of protons with radiofrequency field amplitudes comparable to those used for the rare-spin refocusing and dephasing π pulses results in accurate, high-sensitivity determinations of internuclear distances ...

Diatoms are unicellular phytoplankton accounting for ∼40% of global marine primary productivity, yet the molecular mechanisms underlying their ecological success are largely unexplored. We use a functional-genomics approach ...

The development of stable spherical lipid-coated drug particles that are termed ‘lipocores’ is reported here. Unlike conventional lipid-based particles (i.e. liposomes, emulsions, micelles), these particles are comprised ...

Emiliania huxleyi is an abundant unicellular marine alga and an essential part of the food web. E. huxleyi removes carbon dioxide from the oceans and atmosphere by two processes: photosynthesis and the production of a ...