Recent in vivo experiments have illustrated the importance of understanding the haemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between haemodynamic ...

Most biological functional systems are complex, and this complexity is a fundamental driver of diversity. Because input parameters interact in complex ways, a holistic understanding of functional systems is key to understanding ...

Numerous fluid-structure interaction problems in biology have been investigated using the immersed boundary method. The advantage of this method is that complex geometries, e.g., internal or external morphology, can easily ...

The immersed boundary (IB) method is an elegant way to fully couple the motion of a fluid and deformations of an immersed elastic structure. In that vein, the IB2d software allows for expedited explorations of fluid-structure ...

The development of fluid-structure interaction (FSI) software involves trade-offs between ease of use, generality, performance, and cost. Typically there are large learning curves when using low-level software to model the ...

In a developing vertebrate heart, the heart does not simply beat just to transport blood, nutrients, and oxygen, but it beats to aid in the formation.

This article provides models and code for numerically simulating muscle–fluid–structure interactions (FSIs). This work was presented as part of the symposium on Leading Students and Faculty to Quantitative Biology through ...

Trabeculae begin to form in the human developing heart for Reynolds numbers on the order of 10. Other hearts, such as the squid heart, have trabeculae for Re on the order of 10 and larger. The effect of trabeculae on the ...

Trabeculae form in developing zebrafish hearts for Re on the order of 0.1; effects of trabeculae in this flow is not well understood. Dynamic processes, such as vortex formation, are important in the generation of shear ...