Recent in vivo experiments have illustrated the importance of understanding the haemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between haemodynamic ...

Around the third week after gestation in embryonic development, the human heart consists only of a valvless tube, unlike a fully developed adult heart, which is multi-chambered. At this stage in development, the heart ...

Proper heart morphogenesis requires a delicate balance between hemodynamic forces, myocardial activity, morphogen gradients, and epigenetic signaling, all of which are coupled with genetic regulatory networks. Recently ...

We explore an embryonic heart model that couples electrophysiology and muscle-force generation to flow induced using a 2𝘋 fluid-structure interaction framework based on the immersed boundary method. The propagation of ...

The vertebrate heart begins to pump when its morphology is nothing more than a valveless tube, composed of an outer layer of myocardial cells surrounding an inner layer of endocardial cells. It has been proposed that the ...