Now showing items 21-30 of 142
Reaction of dimethyl sulfoxide with isatoic anhydrides. Isolation of unexpected rearrangement products
(American Chemical Society, 2007-05)
Reaction of thermolabile aryllithium reagents with N-methylisatoic anhydride
(Bristol-Myers Squibb, 2006-10)
Mean survival times of absorbing triply periodic minimal surfaces
(American Physical Society, 2009)
Understanding the transport properties of a porous medium from a knowledge of its microstructure is a problem of great interest in the physical, chemical and biological sciences. Using a first passage time method, we compute ...
The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors
(Taylor & Francis, 2008)
The majority of gastrointestinal stromal tumors (GISTs) are characterized by oncogenic gain-of-function mutations in the receptor tyrosine kinase (RTK) c-KIT with a minority in PDGFRa. Therapy for GISTs has been revolutionized ...
iReference: Using Apple's iPhone as a Reference Tool
Gene function analysis
(Humana Press, 2007)
Probing the Folding Intermediate of Rd-apocyt b562 by Protein Engineering and Infrared T-jump
(John Wiley & Sons, Inc., 2007)
Small proteins often fold in an apparent two-state manner with the absence of detectable early-folding intermediates. Recently, using native-state hydrogen exchange, intermediates that exist after the rate-limiting transition ...
Detection of Treatment-Induced Changes in Signaling Pathways in Gastrointestinal Stromal Tumors Using Transcriptomic Data
(American Association for Cancer Research, 2009)
Cell signaling plays a central role in the etiology of cancer. Numerous therapeutics in use or under development target signaling proteins; however, off-target effects often limit assignment of positive clinical response ...
Growing heterogeneous tumors in silico
(The American Physical Society, 11/16/2009)
An in silico tool that can be utilized in the clinic to predict neoplastic progression and propose individualized treatment strategies is the holy grail of computational tumor modeling. Building such a tool requires the ...
Condensation of Tricyclic Pyrrolopyridine Diones and an Isoindoline Dione with Methylnitronate Anion
(Walter de Gruyter, 2006)