Now showing items 1-2 of 2
Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
(American Academy of Mathematical Sciences, 2016-12)
While chemoresistance in primary tumors is well-studied, much less is known about the influence of systemic chemotherapy on the development of drug resistance at metastatic sites. In this work, we use a hybrid spatial model ...
Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model
(Springer Verlag, 2015)
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular ...