Now showing items 1-10 of 109
Building context with tumor growth modeling projects in differential equations
(Taylor & Francis, 2015)
The use of modeling projects serves to integrate, reinforce, and extend student knowledge. Here we present two projects related to tumor growth appropriate for a first course in differential equations. They illustrate the ...
Matrix Factorization Methods Applied in Microarray Data Analysis
Numerous methods have been applied to microarray data to group genes into clusters that show similar expression patterns. These methods assign each gene to a single group, which does not reflect the widely held view among ...
A Novel Three-Phase Model of Brain Tissue Microstructure
(Public Library of Science, 8/15/2008)
We propose a novel biologically constrained three-phase model of the brain microstructure. Designing a realistic model is tantamount to a packing problem, and for this reason, a number of techniques from the theory of ...
A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
(Libertas Academica, 2007)
Background: The Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC, http://www.pcabc.upmc.edu) is one of the first major project-based initiatives stemming from the Pennsylvania Cancer Alliance that was funded ...
Hybrid modeling of cell signaling and transcriptional reprogramming and its application in C. elegans development
(Frontiers Media, 2011)
Modeling of signal driven transcriptional reprogramming is critical for understanding of organism development, human disease, and cell biology. Many current modeling techniques discount key features of the biological ...
Course-related materials at the University of Denver: A collaboration: Why collaborate?
(Association of College & Research Libraries, 2007)
The Patrons Demand, But What Do They Really Want?
In the last few years, the acceptance and adoption of eBooks in libraries has gained considerable momentum. As platforms become more user-friendly, tablet readers proliferate, and, most notably, aggregators ramp up their ...
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network
(Impact Journals, 2016)
Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways ...
Sneak peek: Raptors search for prey using stochastic head turns
(Central Ornithology Publication Office, 2017)
The strategies by which foraging predators decide when to redirect their gaze influence both prey detection rates and the prey's ability to detect and avoid predators. We applied statistical analyses that have been used ...
Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance
A tumor vasculature that is functionally abnormal results in irregular gradients of metabolites and drugs within the tumor tissue. Recently, significant efforts have been committed to experimentally examine how cellular ...