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An Expedient in situ Preparation of Symmetrical 1,4-Dibenzylpiperazines from Benzyl Bromides and 2-Bromoethylamine Hydrobromide
(Elsevier, 8/24/2010)
A straightforward synthesis of a variety of 1,4-bis-benzylpiperazines from benzyl halides and 2-bromoethylamine hydrobromide is described.
1-Methyl-2H-1,3-benzoxazine-2,4(1H)dione
(International Union of Crystallography, 2010)
The article discusses a study about the crystal structure of the organic compound C9H7NO3. The centroid-centroid distance between the benzenoid and the 2,4 dicarbonyl oxazine rings of π-stacked dimers formed by the crystal ...
Expedient Preparations of 4,6-Dihalo-3-arylisobenzofuran-1(3H)-ones from 3,5-Dihalo-N-ethylbenzamides
(Taylor & Francis, 8/12/2010)
Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides
(Scientific Research Publishing, 2016)
Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ...
Reaction of Functionalized Aryllithium Reagents with N-Alkylisatoic Anhydrides. A Straight forward Route to 2’-Substituted 2-N-Alkylaminobenzophenone Derivatives
(Manind Publishing Company, 2016)
N-Substituted isatoic anhydrides have been found to cleanly undergo acylation with Parham reagents (highly elctrophillic
functional group-substituted aryllithium reagents) followed by elimination of ...
A Parham Cyclization route to the 2,3-dihydro 1H-indazole-1,2-dicarboxylate ring system via condensation of thermolabile aryllithium reagents and azodicarboxylate esters
(Elsevier, 2017)
The Parham Cyclization reaction of o-lithiobenzyl chlorides (generated by low temperature halogen-metal exchange of the corresponding o-bromobenzyl chlorides with n-butyllithium) with azodicarboxylate esters provides a new ...
An unexpected aromatization reaction during the preparation of 1,2-cyclohexanedione ethers
(ACG Publications, 2017)
In a heretofore-unreported reaction, 1,2-cyclohexandione reacts with a variety of alcohols under mild acid-catalyzed dehydration conditions to afford not only ethers of 1,2- cyclohexanedione but the corresponding aryl ...
The reaction of isatoic anhydride with dimethylsulfoxide. Isolation of products formed through a putative Pummerer rearrangement
(Manind Publishing Company, 2016)
Reaction of isatoic anhydride with dimethyl sulfoxide at 150oC results in the formation of S-methyl-2-aminobenzothioate as the result of a Pummerer rearrangement. While the reaction can be conducted in the absence ...
Thermolysis reactions of N-alkyl-N′-CBZ amino acid amides. A route to substituted imidazolidine-2,4-diones
(Elsevier, 2018)
Reaction of N-alkyl-N′-CBZ amino acid amides under microwave conditions in water and in the presence of an acid catalyst results in the formation of N-substituted imidazolidine-2,4-diones in good yields.
Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides
(Scientific Research Publishing, 2016)
Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ...