Now showing items 1-10 of 29
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network
(Impact Journals, 2016)
Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways ...
Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance
A tumor vasculature that is functionally abnormal results in irregular gradients of metabolites and drugs within the tumor tissue. Recently, significant efforts have been committed to experimentally examine how cellular ...
Guide to the solo horn repertoire
(Indiana University Press, 2016)
Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
(American Academy of Mathematical Sciences, 2016-12)
While chemoresistance in primary tumors is well-studied, much less is known about the influence of systemic chemotherapy on the development of drug resistance at metastatic sites. In this work, we use a hybrid spatial model ...
Exploring the Information Literacy Needs and Values of High School Chemistry Teachers
(American Chemical Society, 2016)
A thirty-year reflection on the value of reference
(American Library Association, 2016)
As RUSA is exploring how, if at all, the word “reference” succeeds in describing what its members do in the twenty-first-century library, it seemed an opportune moment to publish David Murray’s column reflecting on reference ...
Finding causative genes from high-dimensional data: an appraisal of statistical and machine learning approaches
(De Gruyter, 2016-08)
Modern biological experiments often involve high-dimensional data with thousands or more variables. A challenging problem is to identify the key variables that are related to a specific disease. Confounding this task is ...
Linking job design to subjective career success: a test of self-determination theory
(SAGE Publications, 2016)
We tested a predictive model based on self-determination theory (SDT) to demonstrate how job design choices contribute to subjective career success. Data collected at Time 1 demonstrated that the job characteristics of ...
The SL(2,C) Casson invariant for knots and the Aˆ-polynomial
(Canadian Journal of Mathematics, 2016)
In this paper, we extend the definition of the SL(2, C) Casson invariant to arbitrary knots K in integral homology 3-spheres and relate it to the m-degree of the (A) over cap -polynomial of K. We prove a product formula ...
Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination
(Libertas Academica, 2016)
The goal of this study was to discover a minimally invasive pathway-specific biomarker that is immune to normal cell mRNA contamination for diagnosing head and neck squamous cell carcinoma (HNSCC). Using Elsevier's MedScan ...