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Activation of the NOTCH Pathway in Head and Neck Cancer
(American Association for Cancer Research, 2014)
NOTCH1 mutations have been reported to occur in 10% to 15% of head and neck squamous cell carcinomas (HNSCC). To determine the significance of these mutations, we embarked upon a comprehensive study of NOTCH signaling in ...
Correcting transcription factor gene sets for copy number and promoter methylation variations
Gene set analysis provides a method to generate statistical inferences across sets of linked genes, primarily using high-throughput expression data. Common gene sets include biological pathways, operons, and targets of ...