Now showing items 1-4 of 4
Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance
A tumor vasculature that is functionally abnormal results in irregular gradients of metabolites and drugs within the tumor tissue. Recently, significant efforts have been committed to experimentally examine how cellular ...
Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
(American Academy of Mathematical Sciences, 2016-12)
While chemoresistance in primary tumors is well-studied, much less is known about the influence of systemic chemotherapy on the development of drug resistance at metastatic sites. In this work, we use a hybrid spatial model ...
Finding causative genes from high-dimensional data: an appraisal of statistical and machine learning approaches
(De Gruyter, 2016-08)
Modern biological experiments often involve high-dimensional data with thousands or more variables. A challenging problem is to identify the key variables that are related to a specific disease. Confounding this task is ...
Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs
The tumor-associated microvasculature is one of the key elements of the microenvironment that helps shape, and is shaped by, tumor progression. Given the important role of the vasculature in tumor progression, and the fact ...