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Building context with tumor growth modeling projects in differential equations
(Taylor & Francis, 2015)
The use of modeling projects serves to integrate, reinforce, and extend student knowledge. Here we present two projects related to tumor growth appropriate for a first course in differential equations. They illustrate the ...
Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model
(Springer Verlag, 2015)
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular ...
Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections
(American Academy of Mathematical Sciences, 2015-12)
Oncolytic viruses (OVs) are used to treat cancer, as they selectively replicate inside of and lyse tumor cells. The efficacy of this process is limited and new OVs are being designed to mediate tumor cell release of cytokines ...