Now showing items 21-30 of 36
OnionTree XML: A Format to Exchange Gene-Related Probabilities
(Taylor & Francis, 2011)
ZNF-Mediated Resistance to Imatinib Mesylate in Gastrointestinal Stromal Tumor
(Public Library of Science, 2013)
Although imatinib mesylate (IM) has transformed the treatment of gastrointestinal stromal tumors (GIST), many patients experience primary/secondary drug resistance. In a previous study, we identified a gene signature, ...
Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination
(Libertas Academica, 2016)
The goal of this study was to discover a minimally invasive pathway-specific biomarker that is immune to normal cell mRNA contamination for diagnosing head and neck squamous cell carcinoma (HNSCC). Using Elsevier's MedScan ...
NF‐κB and stat3 transcription factor signatures differentiate HPV‐positive and HPV‐negative head and neck squamous cell carcinoma
Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the ...
Knowledge-based data analysis comes of age
(Oxford University Press, 2010)
The emergence of high-throughput technologies for measuring biological systems has introduced problems for data interpretation that must be addressed for proper inference. First, analysis techniques need to be matched to ...
Serum microRNA Biomarkers for Detection of Non-Small Cell Lung Cancer
(Public Library of Science, 2012)
Non small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality world-wide and the majority of cases are diagnosed at late stages of disease. There is currently no cost-effective screening test for ...
A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice
(Nature Publishing Group, 2014)
Overexpression of the NEDD9/HEF1/Cas-L scaffolding protein is frequent, and drives invasion and metastasis in breast, head and neck, colorectal, melanoma, lung and other types of cancer. We have examined the consequences ...
Expression Microarray Analysis Reveals Alternative Splicing of LAMA3 and DST Genes in Head and Neck Squamous Cell Carcinoma
(Public Library of Science, 2014)
Purpose Prior studies have demonstrated tumor-specific alternative splicing events in various solid tumor types. The role of alternative splicing in the development and progression of head and neck squamous cell carcinoma ...
An argument for mechanism-based statistical inference in cancer
(Springer Verlag, 2015)
Cancer is perhaps the prototypical systems disease, and as such has been the focus of extensive study in quantitative systems biology. However, translating these programs into personalized clinical care remains elusive and ...
Updating annotations with the distributed annotation system and the automated sequence annotation pipeline
(Oxford University Press, 2012)
The integration between BioDAS ProServer and Automated Sequence Annotation Pipeline (ASAP) provides an interface for querying diverse annotation sources, chaining and linking results, and standardizing the output using the ...