Chemistry Department
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Selected publications and research from Chemistry Faculty
Recent Submissions
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Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides
(Scientific Research Publishing, 2016)Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ... -
Reaction of Functionalized Aryllithium Reagents with N-Alkylisatoic Anhydrides. A Straight forward Route to 2’-Substituted 2-N-Alkylaminobenzophenone Derivatives
(Manind Publishing Company, 2016)N-Substituted isatoic anhydrides have been found to cleanly undergo acylation with Parham reagents (highly elctrophillic functional group-substituted aryllithium reagents) followed by elimination of ... -
The reaction of isatoic anhydride with dimethylsulfoxide. Isolation of products formed through a putative Pummerer rearrangement
(Manind Publishing Company, 2016)Reaction of isatoic anhydride with dimethyl sulfoxide at 150oC results in the formation of S-methyl-2-aminobenzothioate as the result of a Pummerer rearrangement. While the reaction can be conducted in the absence ... -
An unexpected aromatization reaction during the preparation of 1,2-cyclohexanedione ethers
(ACG Publications, 2017)In a heretofore-unreported reaction, 1,2-cyclohexandione reacts with a variety of alcohols under mild acid-catalyzed dehydration conditions to afford not only ethers of 1,2- cyclohexanedione but the corresponding aryl ... -
A Parham Cyclization route to the 2,3-dihydro 1H-indazole-1,2-dicarboxylate ring system via condensation of thermolabile aryllithium reagents and azodicarboxylate esters
(Elsevier, 2017)The Parham Cyclization reaction of o-lithiobenzyl chlorides (generated by low temperature halogen-metal exchange of the corresponding o-bromobenzyl chlorides with n-butyllithium) with azodicarboxylate esters provides a new ... -
Thermolysis reactions of N-alkyl-N′-CBZ amino acid amides. A route to substituted imidazolidine-2,4-diones
(Elsevier, 2018)Reaction of N-alkyl-N′-CBZ amino acid amides under microwave conditions in water and in the presence of an acid catalyst results in the formation of N-substituted imidazolidine-2,4-diones in good yields. -
Modified Birch Reduction for the Introductory Undergraduate Organic Laboratory
(American Chemical Society, 2014)The Birch reduction is a reaction commonly taught in the second-year undergraduate organic curriculum that involves the reduction of an aromatic compound to an alicyclic product using sodium metal and liquid ammonia. The ... -
Metalation Reaction of 3,5-Dichloro-N-ethylbenzamide
(The College of New Jersey, 1999)The metalation reaction of 3,5-dichloro-Nethylbenzamide was compared with that of 3,5-dichloro-N,N-diethylbenzamide in order to study the effects of regioselectivity and sterics of the functional groups. This is a ... -
Metalation Reactions of 3,5-Dichloro-N,N-diethylbenzamide
(The College of New Jersey, 1998)The competing influences of regiocontrol of the diethylamido and chloro functional groups were examined in the metalation reactions of 3,5-dichloro-N,N-diethylbenzamide. The compounds, 3,5-dichloro-4-methyl-N,Ndiethylbenzamide ... -
Epoxidation of Geraniol: An Advanced Organic Experiment that Illustrates Asymmetric Synthesis
(American Chemical Society, 1997)The Sharpless epoxidation reaction is considered one of the most powerful advances in asymmetric organic synthesis (1). It is a classic example of the use of an asymmetric catalyst to provide an enantiomerically enriched ... -
Kinetics of phase-transfer-catalyzed oxidations ofp-substituted benzyl alcohols with aqueous hypochlorite
(Springer Verlag, 1997)A series ofp-substituted benzyl alcohols have been oxidized to their corresponding aldehydes using aqueous hypochlorite and phase-transfer catalyst (PTC) conditions. The reaction constant, p, has been determined to be ... -
Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides
(Scientific Research Publishing, 2016)Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ... -
β-Nitrostyrenes as Electrophiles in Parham Cyclization Chemistry. Reaction with o-Lithiobenzonitrile
(Elsevier, 2009-06)β-Nitrostyrenes react with o-lithiobenzonitrile, generated from the requisite aryl bromide at −100 °C by bromine–lithium exchange with n-butyllithium in THF, to afford 2-nitro-3-phenyl-3H-inden-1-ylamines resulting from ... -
Uncoupling Activity and Pesticidal Properties of Pyrroles
(Portland Press Ltd., 1994) -
Ultrafast Folding of a Computationally Designed Trp-cage Mutant: Trp2-cage
(American Chemical Society, 2006) -
Truncation of Cross-linked GCN4-p1 Coiled-coil Leads to Ultrafast Folding
(American Chemical Society, 2006) -
Synthesis, Characterization, and Reactivity Studies of (Cyclohexenyl)nickel(II) Complexes
(American Chemical Society, 7/13/2010) -
Synthesis, Characterization, and Reactivity of Arene-Stabilized Rhodium Complexes
(American Chemical Society, 3/29/2011) -
Synthesis of Quinolizinones by the Condensation of Ylidenemalononitriles with Quinoline-1-Oxide
(American Chemical Society, 1977)