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  Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides 

  Hunt, David A.; Khani, Francesca; Fleming, Tina; Collins, Carleton; Tabakin, Erica; Bradley, Lynn M. (Scientific Research Publishing, 2016)

  Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ...
• Reaction of Functionalized Aryllithium Reagents with N-Alkylisatoic Anhydrides. A Straight forward Route to 2’-Substituted 2-N-Alkylaminobenzophenone Derivatives 

  Hunt, David A.; Bertonazzi, Joanne; Thornton, Sarah; Grossman, Alec (Manind Publishing Company, 2016)

  N-Substituted isatoic anhydrides have been found to cleanly undergo acylation with Parham reagents (highly elctrophillic functional group-substituted aryllithium reagents) followed by elimination of ...
• The reaction of isatoic anhydride with dimethylsulfoxide. Isolation of products formed through a putative Pummerer rearrangement 

  Hunt, David A.; Cherney, Emily (Manind Publishing Company, 2016)

  Reaction of isatoic anhydride with dimethyl sulfoxide at 150oC results in the formation of S-methyl-2-aminobenzothioate as the result of a Pummerer rearrangement. While the reaction can be conducted in the absence ...
• An unexpected aromatization reaction during the preparation of 1,2-cyclohexanedione ethers 

  Hunt, David A.; DeAngelis, Ryan; Solinski, Amy (ACG Publications, 2017)

  In a heretofore-unreported reaction, 1,2-cyclohexandione reacts with a variety of alcohols under mild acid-catalyzed dehydration conditions to afford not only ethers of 1,2- cyclohexanedione but the corresponding aryl ...
• A Parham Cyclization route to the 2,3-dihydro 1H-indazole-1,2-dicarboxylate ring system via condensation of thermolabile aryllithium reagents and azodicarboxylate esters 

  Hunt, David A.; Farrokh, John; Craven, Timothy (Elsevier, 2017)

  The Parham Cyclization reaction of o-lithiobenzyl chlorides (generated by low temperature halogen-metal exchange of the corresponding o-bromobenzyl chlorides with n-butyllithium) with azodicarboxylate esters provides a new ...
• Thermolysis reactions of N-alkyl-N′-CBZ amino acid amides. A route to substituted imidazolidine-2,4-diones 

  Hunt, David A.; Casale, Marc (Elsevier, 2018)

  Reaction of N-alkyl-N′-CBZ amino acid amides under microwave conditions in water and in the presence of an acid catalyst results in the formation of N-substituted imidazolidine-2,4-diones in good yields.
• Modified Birch Reduction for the Introductory Undergraduate Organic Laboratory 

  Bradley, Lynn M.; Abourahma, Heba; Lareau, Nichole M.; Reesbeck, Megan (American Chemical Society, 2014)

  The Birch reduction is a reaction commonly taught in the second-year undergraduate organic curriculum that involves the reduction of an aromatic compound to an alicyclic product using sodium metal and liquid ammonia. The ...
• Metalation Reaction of 3,5-Dichloro-N-ethylbenzamide 

  Bradley, Lynn M.; Hunt, David A.; Fitzgerald, Patricia (The College of New Jersey, 1999)

  The metalation reaction of 3,5-dichloro-Nethylbenzamide was compared with that of 3,5-dichloro-N,N-diethylbenzamide in order to study the effects of regioselectivity and sterics of the functional groups. This is a ...
• Metalation Reactions of 3,5-Dichloro-N,N-diethylbenzamide 

  Bradley, Lynn M.; Demas, Maria (The College of New Jersey, 1998)

  The competing influences of regiocontrol of the diethylamido and chloro functional groups were examined in the metalation reactions of 3,5-dichloro-N,N-diethylbenzamide. The compounds, 3,5-dichloro-4-methyl-N,Ndiethylbenzamide ...
• Epoxidation of Geraniol: An Advanced Organic Experiment that Illustrates Asymmetric Synthesis 

  Bradley, Lynn M.; Springer, Joseph W.; Delate, Gregory M.; Goodman, Andrew (American Chemical Society, 1997)

  The Sharpless epoxidation reaction is considered one of the most powerful advances in asymmetric organic synthesis (1). It is a classic example of the use of an asymmetric catalyst to provide an enantiomerically enriched ...
• Kinetics of phase-transfer-catalyzed oxidations ofp-substituted benzyl alcohols with aqueous hypochlorite 

  Bradley, Lynn M.; Lesica, Jeanne M.; Albertson, Kevin B. (Springer Verlag, 1997)

  A series ofp-substituted benzyl alcohols have been oxidized to their corresponding aldehydes using aqueous hypochlorite and phase-transfer catalyst (PTC) conditions. The reaction constant, p, has been determined to be ...
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  Regioselectivity Differentiation in Metalations of 3,5-Dichloro-Tertiary versus Secondary Benzamides 

  Bradley, Lynn M.; Khani, Francesca; Fleming, Tina; Collins, Carleton; Tabakin, Erica R.; Hunt, David A. (Scientific Research Publishing, 2016)

  Metalation regioslectivity of 3,5-dichlorobenzamides is a function of the type of amide (secondary versus tertiary) used in the sequence. Metalation at the 2-position (adjacent to the carboxamide functional group) occurs ...
• β-Nitrostyrenes as Electrophiles in Parham Cyclization Chemistry. Reaction with o-Lithiobenzonitrile 

  Clarke, Adam J.; Hunt, David A. (Elsevier, 2009-06)

  β-Nitrostyrenes react with o-lithiobenzonitrile, generated from the requisite aryl bromide at −100 °C by bromine–lithium exchange with n-butyllithium in THF, to afford 2-nitro-3-phenyl-3H-inden-1-ylamines resulting from ...
• Uncoupling Activity and Pesticidal Properties of Pyrroles 

  Treacy, M.F.; Miller, T.P.; Black, B.; Gard, I.; Hunt, David A. (Portland Press Ltd., 1994)
• Uncoupling activity and pesticidal properties of pyrroles 

  Treacy, M.F.; Miller, T.P.; Black, B.; Gard, I.; Hunt, David A. (1993-04)
• Ultrafast Folding of a Computationally Designed Trp-cage Mutant: Trp2-cage 

  Bunagan, Michelle R.; Yang, Xi; Saven, Jeffrey G.; Gai, Feng (American Chemical Society, 2006)
• Truncation of Cross-linked GCN4-p1 Coiled-coil Leads to Ultrafast Folding 

  Bunagan, Michelle R.; Cristian, Lidia; DeGrado, William F.; Gai, Feng (American Chemical Society, 2006)
• Synthesis, Characterization, and Reactivity Studies of (Cyclohexenyl)nickel(II) Complexes 

  O’Connor, Abby R.; White, Peter S.; Brookhart, Maurice (American Chemical Society, 7/13/2010)
• Synthesis, Characterization, and Reactivity of Arene-Stabilized Rhodium Complexes 

  O’Connor, Abby R.; Kaminsky, Werner; Heinekey, D. Michael; Goldberg, Karen I. (American Chemical Society, 3/29/2011)
• Synthesis of Quinolizinones by the Condensation of Ylidenemalononitriles with Quinoline-1-Oxide 

  Douglass, James E.; Hunt, David A. (American Chemical Society, 1977)

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