Show simple item record

dc.contributor.authorGevertz, Jana L.
dc.contributor.authorWares, Joanna R.
dc.contributor.authorCrivelli, Joseph j.
dc.contributor.authorYun, Chae-Ok
dc.contributor.authorKim, Peter S.
dc.contributor.authorChoi, Il-Kyu
dc.date.accessioned2017-09-20T21:41:09Z
dc.date.available2017-09-20T21:41:09Z
dc.date.issued2015-12
dc.identifier.citationJ.R. Wares, J.J. Crivelli, C.O. Yun, I.K. Choi, J.L. Gevertz and P.S. Kim, 2015. Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections. Mathematical Biosciences and Engineering 12(6): 1237-1256.en_US
dc.identifier.urihttp://dx.doi.org/10.3934/mbe.2015.12.1237
dc.descriptionThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Mathematical Biosciences and Engineering following peer review. The definitive publisher-authenticated version J.R. Wares, J.J. Crivelli, C.O. Yun, I.K. Choi, J.L. Gevertz and P.S. Kim, 2015. Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections. Mathematical Biosciences and Engineering 12(6): 1237-1256 is available online at: http://dx.doi.org/10.3934/mbe.2015.12.1237en_US
dc.description.abstractOncolytic viruses (OVs) are used to treat cancer, as they selectively replicate inside of and lyse tumor cells. The efficacy of this process is limited and new OVs are being designed to mediate tumor cell release of cytokines and co-stimulatory molecules, which attract cytotoxic T cells to target tumor cells, thus increasing the tumor-killing effects of OVs. To further promote treatment efficacy, OVs can be combined with other treatments, such as was done by Huang et al., who showed that combining OV injections with dendritic cell (DC) injections was a more effective treatment than either treatment alone. To further investigate this combination, we built a mathematical model consisting of a system of ordinary differential equations and fit the model to the hierarchical data provided from Huang et al. We used the model to determine the effect of varying doses of OV and DC injections and to test alternative treatment strategies. We found that the DC dose given in Huang et al. was near a bifurcation point and that a slightly larger dose could cause complete eradication of the tumor. Further, the model results suggest that it is more effective to treat a tumor with immunostimulatory oncolytic viruses first and then follow-up with a sequence of DCs than to alternate OV and DC injections. This protocol, which was not considered in the experiments of Huang et al., allows the infection to initially thrive before the immune response is enhanced. Taken together, our work shows how the ordering, temporal spacing, and dosage of OV and DC can be chosen to maximize efficacy and to potentially eliminate tumors altogether.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Academy of Mathematical Sciencesen_US
dc.subjectOncolytic virotherapy
dc.subjectAdenovirus
dc.subjectCytokines
dc.subjectCo-stimulatory molecules
dc.subjectMathematical model
dc.subjectOrdinary differential equations model
dc.titleTreatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injectionsen_US
dc.typeArticleen_US
dc.typeTexten_US
dc.typePostprinten_US
prism.publicationNameMathematical Biosciences and Engineering
prism.volume12
prism.issueIdentifier6
prism.startingPage1237
prism.endingPage1256
dc.identifier.handlehttps://dr.tcnj.edu/handle/2900/1416


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record