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dc.contributor.authorGevertz, Jana L.en_US
dc.date.accessioned2015-06-25T14:06:23Z
dc.date.available2015-06-25T14:06:23Z
dc.date.issued2011
dc.identifier.citationGevertz, Jana L. (2011). Computational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validation. Computational and Mathematical Methods in Medicine 2011,1-17.en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2011/830515
dc.description.abstractMathematical modeling techniques have been widely employed to understand how cancer grows, and, more recently, such approaches have been used to understand how cancer can be controlled. In this manuscript, a previously validated hybrid cellular automaton model of tumor growth in a vascularized environment is used to study the antitumor activity of several vascular-targeting compounds of known efficacy. In particular, this model is used to test the antitumor activity of a clinically used angiogenesis inhibitor (both in isolation, and with a cytotoxic chemotherapeutic) and a vascular disrupting agent currently undergoing clinical trial testing. I demonstrate that the mathematical model can make predictions in agreement with preclinical/clinical data and can also be used to gain more insight into these treatment protocols. The results presented herein suggest that vascular-targeting agents, as currently administered, cannot lead to cancer eradication, although a highly efficacious agent may lead to long-term cancer control.en_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.titleComputational Modeling of Tumor Response to Vascular-Targeting Therapies—Part I: Validationen_US
dc.typeArticleen_US
dc.typeTexten_US
prism.publicationNameComputational and Mathematical Methods in Medicineen_US
prism.startingPage1
prism.endingPage17
dc.identifier.handlehttps://dr.tcnj.edu/handle/2900/146


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