Now showing items 1-20 of 110

    • Growing heterogeneous tumors in silico 

      Gevertz, Jana L.; Torquato, Salvatore (The American Physical Society, 11/16/2009)
      An in silico tool that can be utilized in the clinic to predict neoplastic progression and propose individualized treatment strategies is the holy grail of computational tumor modeling. Building such a tool requires the ...
    • Comparison of simian immunodeficiency virus isolates 

      Ochs, Michael F.; Kestler, Henry W. III; Li, Yen; Naidu, Yathirajulu M.; Butler, Carole V.; Jaenel, Gerlinde; King, Norval W.; Daniel, Muthiah D.; Desrosiers, Ronald C. (Nature Publishing Group, 1988)
      Information on the extent of genetic variability among non-human primate lentiviruses related to human immunodeficiency virus (HIV) is sorely lacking. Here we describe the isolation of two molecular clones from the simian ...
    • Generalized Casson Invariants for SO(3),U(2),Spin(4) , and SO(4) 

      Curtis, Cynthia (American Mathematical Society, 1994)
      We investigate Casson-type invariants corresponding to the low-rank groups $\mathrm{SO}(3), \mathrm{SU}(2) \times S^1, \mathrm{U}(2), \operatorname{Spin}(4)$ and SO(4). The invariants are defined following an approach ...
    • Commutators in Free Products 

      Clifford, Andrew (World Scientific Publishing, 1995)
      Topological methods are used to show that for certain subgroups S of a free product F, if w∈S is a commutator in F, then w is a commutator in S.
    • Tesselations of S2 and equations over torsion-free groups 

      Clifford, Andrew; Goldstein, Richard Z. (Cambridge University Press, 1995)
      Let G be a torsion free group, F the free group generated by t. The equation r(t) = 1 is said to have a solution over G if there is a solution in some group that contains G. In this paper we generalize a result due to ...
    • A decomposition theorem for h-cobordant smooth simply-connected compact 4-manifolds 

      Curtis, Cynthia; Freedman, M.H.; Hsiang, W.C.; Stong, R. (Springer Verlag, 1996)
    • A New Method for Spectral Decomposition Using a Bilinear Bayesian Approach 

      Ochs, Michael F.; Stoyanova, R.S.; Arias-Mendoza, F.; Brown, T.R. (Elsevier, 1999)
      A frequent problem in analysis is the need to find two matrices, closely related to the underlying measurement process, which when multiplied together reproduce the matrix of data points. Such problems arise throughout ...
    • Compact cores of coverings 

      Clifford, Andrew (Elsevier, 1999)
      Let H be a subgroup of G. In this paper we discuss the following questions: Is there a two-complex L so that pi(1)(L) = G and so that the cover of L corresponding to H has a compact core? Is there an L so that pi(1)(L) = ...
    • Groups and Several Equations in one Variable 

      Clifford, Andrew (World Scientific Publishing, 2001)
      This paper addresses the question of simultaneously solving a set of equations in one variable over torsion-free groups.
    • An intersection theory count of the -representations of the fundamental group of a 3-manifold 

      Curtis, Cynthia (Elsevier, 2001)
      We define an invariant of closed 3-manifolds counting the signed equivalence classes of representations of the fundamental group in . The invariant is an -analog of the Casson-Walker invariant for SU(2). We reinterpret the ...
    • Signal transduction driving technology driving signal transduction: factors in the design of targeted therapies 

      Golemis, E.A.; Ochs, Michael F.; Pugacheva, E.N. (Wiley, 2001)
      A significant number of human diseases can be attributed to defects in cellular signal transduction pathways. Large-scale proteomics projects now in progress seek to better define critical components of signal transduction ...
    • A Dehn surgery description of regular finite cyclic covering spaces of rational homology spheres 

      Curtis, Cynthia (World Scientific Publishing, 2001)
      We provide related Dehn surgery descriptions for rational homology spheres and a class of their regular finite cyclic covering spaces. As an application, we use the surgery descriptions to relate the Casson invariants of ...
    • The Group <G,t|e> When G is Torsion-Free 

      Clifford, Andrew; Goldstein, Richard Z. (Elsevier, 2001)
      In this paper we discuss classes of nontrivial elements in the group with a relative presentation <G, t \e >, where G is torsion free and e is solvable over G.
    • Equations with Torsion-Free Coefficients 

      Clifford, Andrew; Goldstein, Richard Z. (Cambridge University Press, 2001)
      In this paper we generalize techniques used by Klyachko and the authors to prove some tessellation results about S-2. These results are applied to prove the solvability of certain equations with torsion-free coefficients.
    • Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels 

      Ochs, Michael F.; Grant, Jeffrey D.; Broccoli, D.; Muquit, M.; Manion, Frank J.; Tisdall, J. (Future Medicine, 2001)
    • Application of Bayesian Decomposition for analysing microarray data 

      Moloshok, Thomas D.; Klevecz, R.R.; Grant, Jeffrey D.; Manion, Frank J.; Speier, William; Ochs, Michael F. (Oxford University Press, 2002)
      Motivation: Microarray and gene chip technology provide high throughput tools for measuring gene expression levels in a variety of circumstances, including cellular response to drug treatment, cellular growth and development, ...
    • A Class of Exponent-Sum Two Equations Over Groups 

      Clifford, Andrew (Cambridge University Press, 2002)
      In this paper, relative pictures are used to analyze a certain family of exponent-sum two equations over groups.
    • BeoBLAST: distributed BLAST and PSI-BLAST on a Beowulf cluster 

      Ochs, Michael F.; Grant, Jeffrey D.; Dunbrack, R.L.; Manion, Frank J. (Oxford University Press, 2002)
      BeoBLAST is an integrated software package that handles user requests and distributes BLAST and PSI-BLAST searches to nodes of a Beowulf cluster, thus providing a simple way to implement a scalable BLAST system on top of ...
    • Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors 

      Ochs, Michael F.; Frolov, A.; Chahwan, S.; Arnoletti, J.P.; Pan, Z.Z.; Favorova, Olʹga Olegovna; Fletcher, J.; Mehren, Margaret von; Eisenberg, Burton; Godwin, Andrew K. (American Association for Cancer Research, 2003)
      Gastrointestinal stromal tumors (GISTs), defined by the presence of constitutively activated KIT, are the most common gastrointestinal mesenchymal malignancies. This observation has been successfully exploited in clinical ...