Exploring the biomechanics of type IV pilus filaments under force using coarse grained molecular dynamics
Bogin, Bryan A.
Goncalves, Rebecca B.
Baker, Joseph L.
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Type IV Pili (T4P) are long biopolymers made up of thousands of copies of a protein called pilin. T4P are found on a large variety of micro-organisms including Gram-positive and Gram-negative bacteria . It has been experimentally demonstrated that T4P can withstand high tension forces (up to 10,000 times the bacterial bodyweight) and at the same time undergo a reversible conformational change that allows the filament to stretch to three times its original length and become 40% narrower . However, the molecular scale mechanism of this extraordinary transition is still not clear.
Department of Chemistry
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