A tale of two stoichiometrically diverse cocrystals

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Date
2015
Author
Abourahma, Heba
Shah, Dhaval D.
Melendez, Jesus
Johnson, Elizabeth J.
Holman, K. Travis
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Abstract
Abstract
Liquid-assisted grinding of an equimolar amount of pyrazinamide and p-nitrobenzoic acid yields two stoichiometric cocrystals in a 1:1 and 2:1 ratio, respectively. The 2:1 cocrystal was found to be the thermodynamically stable cocrystal based on solid stoichiometric interconversion, solvent-mediated conversion, and solubility studies.
Citation:
Abourahma, H.., Shah, D., Melendez, J., Johnson, E., & Holman, K. (2015). A Tale of Two Stoichiometrically Diverse Cocrystals. Crystal Growth And Design, 15(7), 3101-3104.
Description
Department of Chemistry
URI
https://dx.doi.org/10.1021/acs.cgd.5b00357
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