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dc.contributor.authorOchs, Michael F.
dc.contributor.authorSmith, Ian M.
dc.contributor.authorGlazer, Chad A.
dc.contributor.authorMithani, Suhail
dc.contributor.authorSun, Wenyue
dc.contributor.authorBhan, Sheetal
dc.contributor.authorVostrov, Alexander
dc.contributor.authorAbdullaev, Ziedulla
dc.contributor.authorLobanenkov, Victor
dc.contributor.authorGray, Andrew
dc.contributor.authorLiu, Chunyan
dc.contributor.authorChang, Steven S.
dc.contributor.authorOstrow, Kimberly L.
dc.contributor.authorWestra, William H.
dc.contributor.authorBegum, Shahnaz
dc.contributor.authorDhara, Mousumi
dc.contributor.authorCalifano, Joseph A.
dc.date.accessioned2018-05-12T15:28:46Z
dc.date.available2018-05-12T15:28:46Z
dc.date.issued2009
dc.identifier.citationSmith, I. M., Glazer, C. A., Mithani, S. K., Ochs, M. F., Wenyue, S., Bhan, S., & ... Califano, J. (2009). Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Cancer. Plos ONE, 4(3), 1-15.en_US
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0004961
dc.description.abstractBackground Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to analyze expression in primary head and neck squamous cell carcinoma (HNSCC) and pharmacologically demethylated cell lines to identify aberrantly demethylated and expressed candidate proto-oncogenes and cancer testes antigens in HNSCC. Methodology/Principal Findings We noted coordinated promoter demethylation and simultaneous transcriptional upregulation of proto-oncogene candidates with promoter homology, and phylogenetic footprinting of these promoters demonstrated potential recognition sites for the transcription factor BORIS. Aberrant BORIS expression correlated with upregulation of candidate proto-oncogenes in multiple human malignancies including primary non-small cell lung cancers and HNSCC, induced coordinated proto-oncogene specific promoter demethylation and expression in non-tumorigenic cells, and transformed NIH3T3 cells. Conclusions/Significance Coordinated, epigenetic unmasking of multiple genes with growth promoting activity occurs in aerodigestive cancers, and BORIS is implicated in the coordinated promoter demethylation and reactivation of epigenetically silenced genes in human cancers.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.titleCoordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Canceren_US
dc.typeArticleen_US
dc.typeTexten_US
prism.publicationNamePLOS ONE
prism.volume4
prism.issueIdentifier3
prism.publicationDate2009
dc.identifier.handlehttps://dr.tcnj.edu/handle/2900/2409


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