Reaction of Functionalized Aryllithium Reagents with N-Alkylisatoic Anhydrides. A Straight forward Route to 2’-Substituted 2-N-Alkylaminobenzophenone Derivatives
Hunt, David A.
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N-Substituted isatoic anhydrides have been found to cleanly undergo acylation with Parham reagents (highly elctrophillic functional group-substituted aryllithium reagents) followed by elimination of CO2 to afford novel 2’-substituted 2-N-alkyl-aminobenzophenones difficult to prepare by standard methods. Such derivatives could prove useful as intermediates toward the preparation of novel heterocyclic systems.
Bertonazzi, J.; Thornton, S.; Grossman, A.; Hunt, D.A. “Reaction of functionalized aryllithium reagents with N-alkylisatoic anhydrides. A straightforward route to 2’ substituted 2-N-alkylaminobenzophenone derivatives,” Heterocyclic Lett. 2016, 6, 423 427.
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