Analyzing the Interactions Between Deep Eutectic Solvents (DES) and Insulin
Baker, Joseph L.
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Deep eutectic solvents (DES) are liquids that contain Bronsted-Lowry acids and bases as well as ions. There are a wide range of implications that involve the use of DES, ranging from fields such as pharmaceuticals and biomaterials to aeronautics. 1 Deep eutectic solvents have the ability to interact with and influence the stability of proteins, such as insulin. Their ability to affect the permeability of a surface or membrane makes them particularly useful in drug design. Studies have shown the ability of a common DES, CAGE (choline, geranic acid, and geranate), to successfully deliver proteins through skin, which would otherwise be impermeable to those proteins. Ionic liquids have also been shown to stabilize various proteins, depending on the nature of the interaction.
Department of Chemistry
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