Simulation Study of a Novel Time-Varying Pulse Sequence for Deep Brain Stimulation
Chawla, Avneet S.
Tamashiro, Daniel S.U.
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Deep Brain Stimulation (DBS) utilizes high frequency stimulation (HFS, normally 90-185 Hz) to treat movement disorders such as Parkinson’s disease and other brain diseases. Based on cybernetics, the responses of nervous systems to a prolonged HFS may have a transient phase before establishment of a steady phase. Transient side effects (termed as "onset response") such as paresthesias have been observed in clinic STN-DBS. Synchronous firing of neurons have been observed at the initial phases of hippocampal HFS. For regular DBS persisting for hours, the effect of transient phases only lasting few seconds may be insignificant. However, it may be significant for intermittent or cycle stimulation paradigms used in adaptive or closed-loop stimulations. The objective of this simulation study was to design and test a novel time-varying pulse sequence to minimize DBS onset response. This may provide a safer stimulation for adaptive or closed-loop DBS with frequent on/off cycles. The results of our study show that the pulse sequence with time-varying parameters that combine ramped intensity with attenuating frequency can induce fast APS suppression during the onset phase of stimulation, avoiding synchronous firings among large populations of neurons that may cause tissue damage. They suggest a novel stimulation paradigm to increase clinical safety of DBS.
Department of Biomedical Engineering
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