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dc.contributor.authorBaker, Joseph L.
dc.contributor.authorWebb, Emma M.
dc.descriptionDepartment of Chemistryen_US
dc.description.abstractOur group is using computer simulations to investigate the strength of bacterial filaments called type IV pili. Type IV pili extend from bacterial cells and are used in a wide variety of functions, including adhesion, motility, and infection. They are made of many copies of a protein called pilin, and can withstand very large tension forces. When type IV pili are stretched, they are known to elongate by approximately three times their initial length, and become significantly smaller in diameter. However, the details of this structural transition are unknown at the molecular scale. Our goal is to provide insight into how the structure of type IV pili change under force, which will provide a basic understanding of the strength and flexibility of these biopolymers.en_US
dc.description.sponsorshipCollege of New Jersey (Ewing, N.J.). Office of Academic Affairsen_US
dc.description.sponsorshipMUSE (Mentored Undergraduate Summer Experience)en_US
dc.description.sponsorshipNational Science Foundation (U.S.)en_US
dc.rightsFile access restricted due to FERPA regulationsen-US
dc.titleSimulating the Mechanism of Elongation in E. Coli Type IV Pili Filaments Using Steered Molecular Dynamicsen_US

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