The Effect of Neat Ionic Liquid on the Folding of Short Peptides
Abstract
Abstract
Using circular dichroism spectroscopy, we show evidence of unusual folding behaviour for several designed peptides in neat ionic liquid. Helical peptides, AKA2 and Trp-cage, exhibit heat-induced folding, with stable helical structure persisting to 96 °C, whereas the β-hairpin Trpzip4 is destabilized by the neat [C4mpy][Tf2N].
Citation:
Huang, J.L.; Noss, M.E.; Schmidt, K.M.; Murray, L.; Bunagan, M.R."The Effect of Neat Ionic Liquid on the Folding of Short Peptides," Chemical Communications. 2011 47, 8007-8009.
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