The Effect of Neat Ionic Liquid on the Folding of Short Peptides
Huang, Jia Lin
Noss, Michael E.
Schmidt, Karson M.
Bunagan, Michelle R.
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Using circular dichroism spectroscopy, we show evidence of unusual folding behaviour for several designed peptides in neat ionic liquid. Helical peptides, AKA2 and Trp-cage, exhibit heat-induced folding, with stable helical structure persisting to 96 °C, whereas the β-hairpin Trpzip4 is destabilized by the neat [C4mpy][Tf2N].
Huang, J.L.; Noss, M.E.; Schmidt, K.M.; Murray, L.; Bunagan, M.R."The Effect of Neat Ionic Liquid on the Folding of Short Peptides," Chemical Communications. 2011 47, 8007-8009.
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