The effect of binding mode on ferric thiolate reactivity

Abstract

Cysteine Dioxygenase (CDO) regulates cysteine levels in the body. Irregular cysteine concentrations are linked to neurological disorders (Alzheimer's, Parkinson's) and autoimmune diseases (lupus, arthritis). CDO enforces S,N coordination using an arginine residue that prevents the carboxylate from binding to the metal center. Hypotheses for this study are 1) that controlling the binding mode of cysteine will affect reactivity; and 2) that S,N will react faster than S,O.