Minimal model of directed cell motility on patterned substrates

Abstract

Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while a those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern geometry and the strength of actin polymerization on the directionality of the crawling cell. These results reveal that high strength of actin polymerization results in motion perpendicular to substrate stripes only when the substrate is relatively non-adhesive; in particular this suggests potential applications in motile cell sorting and guiding on engineered substrates.