The impact of n-terminal strand removal on the structure and functionality of the s-ena pili on bacterial endospores
Abstract
Abstract
Bacillus cereus sensu lato is a group of Gram-positive human and animal pathogens, which (as a survival mechanism) are able to become endospores that can withstand starvation, antimicrobials, wet heat, radiation, and strong chemical conditions. These
bacterial endospores are covered in resilient hair-like appendages that have two conformations called L-Ena and S-Ena. The S-Ena has a “staggered” appearance and is the main focus of the study. Using molecular dynamics simulation software and
methodologies, a mutation of the S-Ena pili was created through the deletion of the N-terminal strand. Analysis of the mutation revealed many changes in the pili’s structural integrity and functionality.
Description
Chemistry Department
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