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dc.contributor.authorPianin, Erika
dc.contributor.authorDawson, Oscar
dc.contributor.authorWynne, David
dc.date.accessioned2017-01-14T20:17:20Z
dc.date.available2017-01-14T20:17:20Z
dc.date.issued2016
dc.descriptionDepartment of Biologyen_US
dc.description.abstractWe are investigating the roles of hasp-2 and icp-1 genes in chromosomal segregation of meiosis in Caenorhabditis elegans. HASP-2 and ICP-1 are part of the chromosomal passenger complex (CPC), which is responsible for loss of sister chromatid cohesion in mitosis. HASP-2 is a kinase that phosphorylates histone H3, leading to CPC activation, and ICP-1 is a linkage between other CPC proteins. Using CRISPR/Cas9 technology, we plan to determine if HASP-2 and ICP-1 also play a role in homologous chromosome separation in meiosis I. We plan to use a co-CRISPR strategy with ICP-1 and a coconversion strategy with HASP-2. hasp-2 and icp-1 mutant animals will then be phenotyped to determine the genes’ functions.en_US
dc.description.sponsorshipMUSE (Mentored Undergraduate Summer Experience)en_US
dc.description.sponsorshipCollege of New Jersey (Ewing, N.J.). Office of Academic Affairsen_US
dc.language.isoen_USen_US
dc.rightsFile access restricted due to FERPA regulations
dc.titleDesigning tools to investigate the roles of hasp-2 and icp-1 in the regulation mode of meiosisen_US
dc.typePosteren_US
dc.typePresentationen_US
dc.typeTexten_US
dc.identifier.handlehttps://dr.tcnj.edu/handle/2900/737


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